240 Lactobacillus crispatus probiotic for skin antiaging benefits
نویسندگان
چکیده
We previously showed that significantly lower populations of Lactobacilli were observed in a cohort aged donors with no Lactobacillus crispatus (LBC) detectable the wrinkle hollows. The aim our study was to demonstrate LBC efficacy vitro, then design formula maintain an efficient delivery living probiotic show significant antiaging clinical results. isolated from healthy skin and checked by full genome sequencing. After optimized growth part biomass kept alive freeze-dried (109 colony forming units/g (cfu/g), whereas other heat killed. effect on synthesis collagen type I V evaluated fibroblast DELFIA method. first tested viability several formulating ingredients up 24h. Some formulations 168 days at different temperatures. One formulation used deliver strain 29 Caucasian women (45-65 years old). dermis density measured after 3 8 weeks ultrasound imaging coupled image analysis, analyzed VISIA CR imaging. stimulated content versus untreated (+133% +55%) inactivated bacteria inefficient. In formulation, viable stable some natural oil-based emollients for weeks, but only few hours emulsifiers mild preservatives. Thus, we designed application routine test which oily serum concentrated booster diluted before neutral emulsion 5 105 cfu/g skin. 2 months twice-daily application, sub-epidermal zone increased vs baseline 11% 6% (+5% placebo). same tendency obtained forehead thickness improvement. demonstrated benefits native compared stimulate vitro. Moreover, improved appearance vivo.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.09.251